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澳門新葡官網進入 學校首頁 | 學院首頁 
         
崔純瑩

姓名:崔純瑩

性別:女

職稱:教授

招生院所:藥劑學系

招生類型:碩士

招生專業:藥劑學

研究方向名稱:基因藥學

電子信箱:ccy@ccmu.edu.cn

個人簡介

    開展新型載體材料研究,包括靶向制劑、緩控釋制劑和基因載體系統的研究工作。利用多種模擬模型和新技術加強通過細胞和分子層次的結構與功能研究,由體內反饋情報指導靶向于細胞水平的給藥系統的設計,以更為穩定、有效地實現體內輸送。以抗腫瘤藥物和基因片段作為研究對象,應用腫瘤細胞模型和生物物理技術為研究手段,通過載體結構及其組分對藥物經細胞膜擴散的影響、對細胞內基因的表達、蛋白表達的變化規律為指標,在穩定性和跨膜轉運機理等研究基礎上進行載體系統設計和制備。建立研究跨膜機制,吸收機制、細胞模型、表達譜測定模型、藥物體外釋放與體內吸收相關性研究平臺。作為學術骨干曾參與北京市教委科研基地-藥物基因組學科技創新平臺建設項目。作為項目負責人已完成北京市教委面上項目(2008年),北京市中青年骨干教師項目(2009年),北京市優秀人才資助(2009年),澳門新葡官網進入基礎-臨床重點課題(2011年),澳門新葡官網進入基礎-臨床面上課題(2010年),中國第55批博士后科學基金面上資助(2013年),北京市屬高等學校高層次人才引進與培養-青年拔尖人才培育項目(2013-2015)?,F負責承擔國家自然科學基金面上青年項目1項(2016-2018),澳門新葡官網進入基礎臨床面上乙方項目1項(2016-2018),澳門新葡官網進入校長基金項目1項(2016-2017)。申請國家發明專利4項,其中作為第1發明人1項。國外SCI論文15篇,其中第一或責任作者9篇,發表國內刊物論文14篇。

 

教育經歷

19959-19998 北京醫科大學澳門新葡官網進入 學士學位

20019-20068 北京大學澳門新葡官網進入 博士學位

20043-20064 新加坡國立大學附屬醫院 血液腫瘤科聯培博士

20137-20157 澳門新葡官網進入 博士后

 

工作經歷

19999-20018 北京大學醫學部

20068 至今 澳門新葡官網進入

 

重要學術論文

1.Yanzhao Bi, Yifan Zhang, Chunying Cui*, Lulu Ren, Xueyun Jiang. Gene-silencing effects of anti-survivin siRNA delivered by RGDV-functionalized nanodiamond carrier in the breast carcinoma cell line MCF-7. Int J Nanomedicine. 2016,11:5771-5787.

2.Wen Zhao, Yifan Zhang, Xueyun Jiang, Chunying Cui*. Design, synthesis and evaluation of VEG F-siRNA /CRS as a novel vector for gene delivery. Drug Design, Development and Therapy. 2016,10:3851-3865

3.Chunying Cui, Yaonan Wang, Wen Zhao, Kaikai Yang, Xueyun Jiang, Shan Li, Ming Zhao, Yuanbo Song and Shiqi Peng*. RGDS covalently surfaced nanodiamond as a tumor targeting carrier of VEGF-siRNA: synthesis, characterization and bioassay. J. Mater. Chem. B, 2015,39260-9268

4.Chunying Cui, Yuji Wang, Kaikai Yang, Yaonan Wang, Junyu Yang, Jianzhong Xi, Ming Zhao*, Jianhui Wu, and Shiqi Peng*. Preparation and Characterization of RGDS/Nanodiamond as a Vector for VEGF-siRNA Delivery. J. Biomed. Nanotechnol. 2015,11: 70-80

5.Cui Chunying, Wang Y, Wang Y, Zhao M*, Peng S*. Exploring the Relationship between the Inhibition Selectivity and the Apoptosis of Roscovitine-Treated Cancer Cells. J Anal Methods Chem. 2013;2013:389390. doi: 10.1155/2013/389390. Epub 2013 Apr 4.

6.Cui Chunying, Wang Y, Wang Y, Zhao M*, Peng S*. Alsterpaullone, a Cyclin-Dependent Kinase Inhibitor, Mediated Toxicity in HeLa Cells through Apoptosis-Inducing Effect. Journal of Analytical Methods in Chemistry Volume  (2013), ttp://dx.doi.org/10.1155/2013/602091

7.Wang F#, Cui Chunying#, Ren Z, Wang L, Liu H, Cui G*. Preparation and biological evaluation of tumor-specific Ara-C liposomal preparations containing RGDV motif. J Pharm Sci. 2012 Dec;101(12):4559-68.

8.Du H#, Cui Chunying#, Wang L, Liu H, Cui G*. Novel Tetrapeptide, RGDF, Mediated Tumor Specific Liposomal Doxorubicin (DOX) Preparations.Mol Pharm. 2011 Aug 1;8(4):1224-32.

9.Chunying Cui, Yunwei Zhang, Lili Wang, Hu Liu and Guohui Cui*. Enhanced anticancer activity of glutamate prodrugs of all-trans retinoic acid. Journal of Pharmacy and Pharmacology 2009; 61: 13531358.

10.Song N, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S*. Nanomedical strategy to prolong survival period, heighten cure rate, and lower systemic toxicity of S180 mice treated with MTX/MIT. Drug Des Devel Ther. 2016 Aug 30;10:2701-11.

11.Lv X, Zhao M, Wang Y, Hu X, Wu J, Jiang X, Li S, Cui C, Peng S*. Loading cisplatin onto 6-mercaptopurine covalently modified MSNS: a nanomedicine strategy to improve the outcome of cisplatin therapy. Drug Design, Development and Therapy.2016,10:3933-3946

12.Meng Q, Yu X, Li C, Zhang C, Cui C, Luo D*. Possible mechanisms underlying the biphasic regulatory effects of arachidonic acid on Ca2+ signaling in HEK293 cells.Chen L, Cell Signal. 2012 Aug;24(8):1565-72. Epub 2012 Mar 30.

13.Liu Boyang, Chunying, Cui, guohuiCui*. Synthesis and evaluation of anti-tumor activities of N4 fatty acyl amino acid derivatives of 1-beta- arabinofuranosylcytosine. Eur J Med Chem 2009, Sep, 01;44(9):3596-600

14.Wen-Son Hsieh, Ross Soo, Bee-Keow Peh, Thomas Loh, Difeng Dong, Donny Soh, Lim-Soon Wong, Simon Green, Judy Chiao, Chunying Cui, Yoke-Fong Lai, Soo-Chin Lee, Benjamin Mow, Richie Soong, Manuel Salto-Tellez and Boon-Cher Goh*. Pharmacodynamic Effects of Seliciclib (R-Roscovitine, CYC202) in Patients with Undifferentiated Nasopharyngeal Cancer (NPC) Using a Window Trial Design. Cancer research. Clinical Cancer Research. 2009 February 15, 151435

15.Chun-Ying Cui, Wan-Liang Lu, Lan Xiao, Qiang Zhang*. Sublingual Delivery of Insulin: Effects of Enhancers on the Mucosal Lipid Fluidity and Protein Conformation, the Transport, and the In Vivo Hypoglycemic Activity. Biological & Pharmaceutical Bulletin, Vol 28 (12)2279-2288, 2005.

 

主編或副主編的著作/譯著

 

重要獎項

1. 澳門新葡官網進入2010年第五屆青年教師教學基本功比賽(英文組)一等獎

2. 化學生物學與澳門新葡官網進入2012年青年教師基本功比賽一等獎

3. 化學生物學與澳門新葡官網進入2010年青年教師基本功比賽一等獎

4. 澳門新葡官網進入2007年《天職與責任》教工演講比賽二等獎

 



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